600 papers
This study demonstrates that while lipoxin treatment does not fully reverse cardiac dysfunction or fibrosis in MLPko mice, it provides sex-specific protective effects by modulating immune cell populations, intercalated disk-associated signaling, and pro-fibrotic gene expression.
This study reveals that the ion channel TRPM2 acts as an intrinsic suppressor of pigmentation by inhibiting a cell-autonomous type-I interferon signaling axis that, when active, stabilizes the master regulator MITF via ISG15 to promote melanogenesis.
This study demonstrates that rapid dephosphorylation of HRS at ER-multivesicular endosome membrane contact sites, mediated by AnnexinA1 and the phosphatase PTP1B, is essential for efficient intraluminal vesicle formation and receptor sorting.
This study demonstrates that SUMO regulates meiotic chromosome architecture by inversely controlling chromatin loop size and axis length, thereby directly influencing crossover frequency and explaining physiological variations in recombination rates across sexes and species.
This paper introduces DeepTracing, a deep generative framework that effectively disentangles intrinsic transcriptional states from lineage-driven effects in single-cell lineage tracing data, outperforming existing methods in clustering, phylogenetic recovery, and trajectory reconstruction across diverse biological contexts.
This study demonstrates that ARP2/3-mediated branched actin, rather than linear actin, is essential for segregating endosomal cargo into distinct subdomains, maintaining these domains, and driving the fission events required for receptor recycling at the early endosome.
This study utilizes acute Pumilio protein degradation to reveal a biphasic post-transcriptional regulatory hierarchy in embryonic stem cells, where Pum1/2 directly destabilize PRC2 subunit mRNAs like Suz12 to modulate chromatin states, thereby controlling pluripotency transitions and lineage specification.
This study demonstrates that the motor activity of nonmuscle myosin 2A (NM2A) is a critical component of its own bipolar filament depolymerization and turnover, a process that cooperates with tail-dependent mechanisms to dynamically reorganize both NM2A and NM2B for efficient cell migration.
This study reveals that while nuclear blebs exhibit variable chromatin modification states across different cell lines, they consistently display an enrichment of RNA Polymerase II transcription initiation relative to elongation.
This study reveals that in adipocytes, ACE2 trafficking is coordinated with insulin-responsive GLUT4 vesicle dynamics, forming a regulated complex that influences ACE2 surface exposure and shedding, thereby linking metabolic signaling to ACE2 cellular behavior with potential implications for metabolic dysfunction and related diseases.
This study identifies FAM53C as a critical regulator of the G1/S cell cycle transition that functions upstream of the CyclinD-CDK4/6-RB and p53 axes by directly inhibiting the kinase DYRK1A, a mechanism validated in both cellular models and human cortical organoids with implications for cancer therapy and developmental disorders.
This study demonstrates that Intraflagellar transport-20 (IFT20) acts as a conserved adaptor in *Chlamydomonas reinhardtii* to guide the ciliary membrane trafficking of channelrhodopsin-1 by interacting with IFT-B and BBSome subunits, thereby elucidating a key mechanism relevant to human ciliopathies.
The study introduces imAgeScore, a machine learning model that leverages Cell Painting morphological features to accurately predict cellular age, enabling high-throughput screening for compounds that modulate aging and validate rejuvenation effects.
This study demonstrates that *Helix aspersa* snail slime induces coordinated proteomic reprogramming and functional benefits in human dermal fibroblasts, including enhanced migration, controlled apoptosis, and redox modulation via key signaling hubs, thereby validating its potential as a regenerative biomaterial for wound healing and anti-aging applications.
This study demonstrates that low-dose aspirin's prophylactic efficacy in preeclampsia is mediated through the reprogramming of chorion trophoblast-derived extracellular vesicle proteomes toward an angiogenic and resilient state, offering a potential molecular framework for stratifying patients who will benefit from personalized aspirin prevention.
This study reveals that the Chikungunya virus transframe (TF) protein uniquely promotes viral propagation by targeting and degrading the host polarity protein Scribble via a specific PDZ-domain binding motif, thereby disrupting cell-cell boundaries to facilitate viral egress without affecting viral assembly.
This study identifies a novel mechanism called TRES (TRanslocon Engagement Surveillance) by which IRE1 senses reduced protein influx into the endoplasmic reticulum via release from unoccupied translocons, triggering a distinct homeostatic response that upregulates the translocation machinery to rebalance ER protein load without activating other UPR branches.
This paper introduces a volumetric fluorescence imaging workflow that calculates depth-dependent attenuation coefficients to quantitatively compare the transparency and staining quality of three CUBIC-based tissue clearing protocols across various murine organs, revealing significant performance differences across protocol-organ combinations.
This paper introduces Fluorescence Anisotropy Structured Illumination Microscopy (FA-SIM), a high-accuracy, low-phototoxicity super-resolution technique that quantitatively maps nanoscale heterogeneity in intracellular viscosity and molecular interactions to reveal the physical regulation of cytoskeletal dynamics and cellular organization.
This study demonstrates that increased interface stress between the plasma membrane and actin barbed ends regulates Arp2/3-branched actin density at the leading edge, enabling cells to drive robust lamellipodial protrusion and spreading in response to high extracellular viscosity even in the absence of extracellular matrix proteins.